Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics InitiativeArticle Published on 2022-11-032022-11-15 Journal: PLoS Genetics [Category] SARS, 변종, 진단, [키워드] analysis Analysis association chromosome Cohort controls country COVID-19 Deleterious disease expected Genetic genetics Genome-wide association study identify increase in initiative loci outcome outcomes Pathogenesis performed rare variant Result severe disease Support susceptibility the SARS-CoV-2 TLR7 Toll-like receptor variant whole-genome sequencing with COVID-19 [DOI] 10.1371/journal.pgen.1010367 PMC 바로가기
The mutation features and geographical distributions of the surface glycoprotein (S gene) in SARS-CoV-2 strains: A comparative analysis of the early and current strainsArticle Published on 2022-11-012022-11-16 Journal: Journal of medical virology [Category] SARS, 변종, [키워드] ACE2-binding region acute respiratory syndrome Analysis analyzed coronavirus coronavirus disease COVID-19 COVID-19 vaccines demonstrated develop Evolution feature Frequency Genome genome mutations geographical distribution highest identify loci mutant strain Mutation omicron prevalent remained Result S gene S protein SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant strain Strains Surface glycoprotein Surface glycoprotein. the receptor-binding domain the S protein The United States United Kingdom Vaccines was used [DOI] 10.1002/jmv.28023 PMC 바로가기
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern HumansArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses [DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
SUMMIT: An integrative approach for better transcriptomic data imputation improves causal gene identificationArticle Published on 2022-10-252022-11-16 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Accuracy analysis approach association Blood build complex component COVID-19 severity dataset eQTL etiology explain expression Gene Expression Genetic Genome-wide association study identify IMPROVE loci low expression modeling moderate proportion provided Quantitative regulated severity Simulation study Statistical power traits transcriptome-wide transcriptomic data with COVID-19 [DOI] 10.1038/s41467-022-34016-y PMC 바로가기
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replicationArticle Published on 2022-10-142022-11-16 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis association Calu-3 cell cellular Comorbidity components COVID-19 demonstrated effective eQTL examined EXOSC2 expression form Genome-wide association study higher risk host protein host-virus interactions human RNA identify impede increased expression interact Interaction loci New nonsense mutation polymerase PROTECT Protein protein expression reduced risk loci RNA RNA polymerase Safe SARS-CoV-2 proteins SARS-CoV-2 replication SARS-CoV-2 viral infection the SARS-CoV-2 therapeutic target Treatment valuable resource viability Viral RNA with COVID-19 [DOI] 10.26508/lsa.202201449 PMC 바로가기
Coronavirus Host Genomics Study: South Africa (COVIGen-SA)Article Published on 2022-10-062022-11-15 Journal: Global health, epidemiology and genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] African black build coronavirus COVID-19 develop ENhance Factor female Genetic genetic information genome-wide association genomic Genomics genomics study Host Host genetic factor loci modify outcome over pandemic participant populations positive promote recruited Research resource risk factor SARS-CoV-2 Sequencing severe disease severity South South Africa susceptibility with COVID-19 with HIV [DOI] 10.1155/2022/7405349 PMC 바로가기
Human genetic basis of severe or critical illness in COVID-19Article Published on 2022-09-202022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome affecting association Asymptomatic base caused contribute coronavirus COVID-19 Critical Critical illness death determinant disease disease severity enhanced Enzymes Factor Genetic Genetic variation genetic. Host Human human leukocyte antigen immune component indicated Interaction Interleukins loci mild infection morbidity and mortality multi-organ dysfunction outcome Precision preventive measure Respiratory failure SARS-CoV-2 SARS-CoV-2 receptor Serine severity of COVID-19 Toll-like receptor transmembrane [DOI] 10.3389/fcimb.2022.963239 PMC 바로가기
Genome-wide association study of SARS-CoV-2 infection in Chinese population중국 인구의 SARS-CoV-2 감염에 대한 게놈 차원의 연관성 연구Article Published on 2022-09-012022-09-11 Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, SARS, 변종, 진단, [키워드] analyzed ANKRD27 association Asymptomatic carried CD200R1L Chinese close contact conducted coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 severity ERAP1 Exome Genetic genetic association genetic variability Genetic variant genetic variants Genome sequencing Genome-wide association study global public health GWAS heterogeneous individual LINC00700 loci locus MAN1A2 molecular NEIL3 pathogenesis of COVID-19 Patient PCNX2 PLCL2 POLR2A Polymorphisms positive provided recruited SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 Sequencing severity single-nucleotide Single-nucleotide polymorphisms suggested susceptibility Susceptibility. symptomatic patient tested therapeutic options ZMAT3 [DOI] 10.1007/s10096-022-04478-5 PMC 바로가기 [Article Type] Article
Distinct evolutionary trajectories of SARS-CoV-2-interacting proteins in bats and primates identify important host determinants of COVID-19박쥐와 영장류에서 SARS-CoV-2 상호작용 단백질의 뚜렷한 진화 궤적은 COVID-19의 중요한 숙주 결정 요인을 식별합니다Article Published on 2022-08-302022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 치료기술, 치료제, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptation adaptive analysis Arm arms race autophagy bat bats caused clinical trial comparative genetics coronavirus coronavirus coronavirus disease COVID-19 COVID-19 severity detection determinant Epidemics functional FYCO1 Genes Genetic genetic determinant Genome genomes Host humans identify in vivo Inflammation Inflammatory involved loci mammalian occurred pandemic Pathogenesis performed Phosphorylation positive Positive selection primates primates and bats Protein Regulation Replication residue residues RIPK1 SARS-CoV SARS-CoV-2 SARS-CoV-2 and COVID-19 SARS-COV-2 infection SARS-CoV-2 susceptibility severe acute respiratory syndrome Coronavirus severe COVID-19 severity signature susceptibility targets TMPRSS2 trajectory Vaccines virus virus–host coevolution. [DOI] 10.1073/pnas.2206610119 PMC 바로가기 [Article Type] Article
A Multitrait Locus Regulates Sarbecovirus PathogenesisArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome analysis approach CCR9 chromosome 9 collaborative cross conserved coronavirus coronavirus disease Coronavirus infection cross CXCR6 disease facilitate Follow-up Genes Genetic genetic determinant genetic mapping Genetic variation GWAS help highly pathogenic Host host response host susceptibility humans identify implementation Infection Infectious disease influence loci locus mice Mortality mouse model outcome outcomes Pathogenesis pathogenic Precision predict Protective regulate sarbecovirus Sarbecoviruses sarbecoviruses. SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2 infections severe disease severity strain susceptibility susceptibility allele variety Viral diseases Virus Disease [DOI] 10.1128/mbio.01454-22 PMC 바로가기